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Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses

Life history theory posits that the sequence and timing of events in an organism's lifespan are fine-tuned by evolution to maximize the production of viable offspring. In a virus, a life history strategy is largely manifested in its replication mode. Here, we develop a stochastic mathematical m...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Schulte, Michael B, Draghi, Jeremy A, Plotkin, Joshua B, Andino, Raul
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311501/
https://ncbi.nlm.nih.gov/pubmed/25635405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03753
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