Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

Tau is the major microtubule-associated protein in neurons involved in microtubule stabilization in the axonal compartment. Changes in tau gene expression, alternative splicing and posttranslational modification regulate tau function and in tauopathies can result in tau mislocalization and dysfuncti...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Biochim Biophys Acta Mol Basis Dis
Päätekijät: Flach, Katharina, Ramminger, Ellen, Hilbrich, Isabel, Arsalan-Werner, Annika, Albrecht, Franziska, Herrmann, Lydia, Goedert, Michel, Arendt, Thomas, Holzer, Max
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2014
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311138/
https://ncbi.nlm.nih.gov/pubmed/24905733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.05.029
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