Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

Tau is the major microtubule-associated protein in neurons involved in microtubule stabilization in the axonal compartment. Changes in tau gene expression, alternative splicing and posttranslational modification regulate tau function and in tauopathies can result in tau mislocalization and dysfuncti...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta Mol Basis Dis
Main Authors: Flach, Katharina, Ramminger, Ellen, Hilbrich, Isabel, Arsalan-Werner, Annika, Albrecht, Franziska, Herrmann, Lydia, Goedert, Michel, Arendt, Thomas, Holzer, Max
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311138/
https://ncbi.nlm.nih.gov/pubmed/24905733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.05.029
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