Hook Proteins: Association with Alzheimer Pathology and Regulatory Role of Hook3 in Amyloid Beta Generation

Defects in intracellular transport are implicated in the pathogenesis of Alzheimer’s disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly expre...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Herrmann, Lydia, Wiegmann, Caspar, Arsalan-Werner, Annika, Hilbrich, Isabel, Jäger, Carsten, Flach, Katharina, Suttkus, Anne, Lachmann, Ingolf, Arendt, Thomas, Holzer, Max
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370497/
https://ncbi.nlm.nih.gov/pubmed/25799409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119423
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