T-DM1, a novel antibody-drug conjugate, is highly effective against uterine and ovarian carcinosarcomas overexpressing HER2

INTRODUCTION: Ovarian and uterine carcinosarcoma (CS) are characterized by their aggressive clinical behavior and poor prognosis. We evaluated the efficacy of trastuzumab-emtansine (T-DM1), against primary HER2 positive and HER2 negative CS cell lines in vitro and in vivo. METHODS: Eight primary CS...

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Publicado no:Clin Exp Metastasis
Main Authors: Nicoletti, Roberta, Lopez, Salvatore, Bellone, Stefania, Cocco, Emiliano, Schwab, Carlton L., Black, Jonathan D., Centritto, Floriana, Zhu, Liancheng, Bonazzoli, Elena, Buza, Natalia, Hui, Pei, Mezzanzanica, Delia, Canevari, Silvana, Schwartz, Peter E., Rutherford, Thomas J., Santin, Alessandro D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310789/
https://ncbi.nlm.nih.gov/pubmed/25398397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10585-014-9688-8
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