Notch inhibition allows oncogene independent generation of iPS cells

The reprogramming of somatic cells to pluripotency using defined transcription factors holds great promise for biomedicine. However, human reprogramming remains inefficient and relies either on the use of the potentially dangerous oncogenes KLF4 and CMYC or the genetic inhibition of the tumor suppre...

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Publicado en:Nat Chem Biol
Autores principales: Ichida, Justin K., TCW, Julia, Williams, Luis A., Carter, Ava C., Shi, Yingxiao, Moura, Marcelo T., Ziller, Michael, Singh, Sean, Amabile, Giovanni, Bock, Christoph, Umezawa, Akihiro, Rubin, Lee L., Bradner, James E., Akutsu, Hidenori, Meissner, Alexander, Eggan, Kevin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310751/
https://ncbi.nlm.nih.gov/pubmed/24952596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1552
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