Experimental Strategies for Functional Annotation and Metabolism Discovery: Targeted Screening of Solute Binding Proteins and Unbiased Panning of Metabolomes

[Image: see text] The rate at which genome sequencing data is accruing demands enhanced methods for functional annotation and metabolism discovery. Solute binding proteins (SBPs) facilitate the transport of the first reactant in a metabolic pathway, thereby constraining the regions of chemical space...

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Pubblicato in:Biochemistry
Autori principali: Vetting, Matthew W., Al-Obaidi, Nawar, Zhao, Suwen, San Francisco, Brian, Kim, Jungwook, Wichelecki, Daniel J., Bouvier, Jason T., Solbiati, Jose O., Vu, Hoan, Zhang, Xinshuai, Rodionov, Dmitry A., Love, James D., Hillerich, Brandan S., Seidel, Ronald D., Quinn, Ronald J., Osterman, Andrei L., Cronan, John E., Jacobson, Matthew P., Gerlt, John A., Almo, Steven C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310620/
https://ncbi.nlm.nih.gov/pubmed/25540822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501388y
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