Effects of an Antisense Oligonucleotide Inhibitor of C‐Reactive Protein Synthesis on the Endotoxin Challenge Response in Healthy Human Male Volunteers

BACKGROUND: C‐reactive protein (CRP) binds to damaged cells, activates the classical complement pathway, is elevated in multiple inflammatory conditions, and provides prognostic information on risk of future atherosclerotic events. It is controversial, however, as to whether inhibiting CRP synthesis...

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Bibliografische gegevens
Gepubliceerd in:J Am Heart Assoc
Hoofdauteurs: Noveck, Robert, Stroes, Erik S. G., Flaim, JoAnn D., Baker, Brenda F., Hughes, Steve, Graham, Mark J., Crooke, Rosanne M., Ridker, Paul M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Blackwell Publishing Ltd 2014
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310401/
https://ncbi.nlm.nih.gov/pubmed/25012289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001084
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