Reducing Endoglin Activity Limits Calcineurin and TRPC‐6 Expression and Improves Survival in a Mouse Model of Right Ventricular Pressure Overload

BACKGROUND: Right ventricular (RV) failure is a major cause of mortality worldwide and is often a consequence of RV pressure overload (RVPO). Endoglin is a coreceptor for the profibrogenic cytokine, transforming growth factor beta 1 (TGF‐β1). TGF‐β1 signaling by the canonical transient receptor prot...

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Detalles Bibliográficos
Publicado en:J Am Heart Assoc
Main Authors: Kapur, Navin K., Qiao, Xiaoying, Paruchuri, Vikram, Mackey, Emily E., Daly, Gerard H., Ughreja, Keshan, Morine, Kevin J., Levine, Jonathan, Aronovitz, Mark J., Hill, Nicholas S., Jaffe, Iris Z., Letarte, Michelle, Karas, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2014
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310384/
https://ncbi.nlm.nih.gov/pubmed/25015075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.000965
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