Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro.

The covalent binding of the hepatocarcinogen aflatoxin B1 by rat liver microsomes to calf thymus DNA resulted in a binding level equal to one aflatoxin residue per 60 DNA nucleotides. An aflatoxin derivative-guanine adduct was efficiently liberated from DNA with formic acid. Analytical reversed-phas...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Essigmann, J M, Croy, R G, Nadzan, A M, Busby, W F, Reinhold, V N, Büchi, G, Wogan, G N
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1977
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431033/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/266709/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.5.1870
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