Investigation of gene effects and epistatic interactions between Akt1 and neuregulin 1 in the regulation of behavioral phenotypes and social functions in genetic mouse models of schizophrenia

Accumulating evidence from human genetic studies has suggested several functional candidate genes that might contribute to susceptibility to schizophrenia, including AKT1 and neuregulin 1 (NRG1). Recent findings also revealed that NRG1 stimulates the PI3-kinase/AKT signaling pathway, which might be...

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Detalhes bibliográficos
Publicado no:Front Behav Neurosci
Main Authors: Huang, Ching-Hsun, Pei, Ju-Chun, Luo, Da-Zhong, Chen, Ching, Chen, Yi-Wen, Lai, Wen-Sung
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310298/
https://ncbi.nlm.nih.gov/pubmed/25688191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2014.00455
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