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Polymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae

Several pathological mutations have been identified in human POLG gene, encoding for the catalytic subunit of Pol γ, the solely mitochondrial replicase in animals and fungi. However, little is known regarding non-pathological polymorphisms found in this gene. Here we studied, in the yeast model Sacc...

詳細記述

保存先:
書誌詳細
出版年:Mitochondrion
主要な著者: Baruffini, Enrico, Ferrari, Jessica, Dallabona, Cristina, Donnini, Claudia, Lodi, Tiziana
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier Science 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309887/
https://ncbi.nlm.nih.gov/pubmed/25462018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2014.11.003
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