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Polymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae

Several pathological mutations have been identified in human POLG gene, encoding for the catalytic subunit of Pol γ, the solely mitochondrial replicase in animals and fungi. However, little is known regarding non-pathological polymorphisms found in this gene. Here we studied, in the yeast model Sacc...

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Bibliografiske detaljer
Udgivet i:Mitochondrion
Main Authors: Baruffini, Enrico, Ferrari, Jessica, Dallabona, Cristina, Donnini, Claudia, Lodi, Tiziana
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309887/
https://ncbi.nlm.nih.gov/pubmed/25462018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2014.11.003
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