Suppression of Tumor Growth in Mice by Rationally Designed Pseudopeptide Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase()

Tumor microenvironments (TMEs) are composed of cancer cells, fibroblasts, extracellular matrix, microvessels, and endothelial cells. Two prolyl endopeptidases, fibroblast activation protein (FAP) and prolyl oligopeptidase (POP), are commonly overexpressed by epithelial-derived malignancies, with the...

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Udgivet i:Neoplasia
Main Authors: Jackson, Kenneth W., Christiansen, Victoria J., Yadav, Vivek R., Silasi-Mansat, Robert, Lupu, Florea, Awasthi, Vibhudutta, Zhang, Roy R., McKee, Patrick A.
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309729/
https://ncbi.nlm.nih.gov/pubmed/25622898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.11.002
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