HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice

Mutant ataxin-1 (Atxn1), which causes spinocerebellar ataxia type 1 (SCA1), binds to and impairs the function of high-mobility group box 1 (HMGB1), a crucial nuclear protein that regulates DNA architectural changes essential for DNA damage repair and transcription. In this study, we established that...

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Udgivet i:EMBO Mol Med
Main Authors: Ito, Hikaru, Fujita, Kyota, Tagawa, Kazuhiko, Chen, Xigui, Homma, Hidenori, Sasabe, Toshikazu, Shimizu, Jun, Shimizu, Shigeomi, Tamura, Takuya, Muramatsu, Shin-ichi, Okazawa, Hitoshi
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2015
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309669/
https://ncbi.nlm.nih.gov/pubmed/25510912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404392
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