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Superoxide anion radicals induce IGF-1 resistance through concomitant activation of PTP1B and PTEN

The evolutionarily conserved IGF-1 signalling pathway is associated with longevity, metabolism, tissue homeostasis, and cancer progression. Its regulation relies on the delicate balance between activating kinases and suppressing phosphatases and is still not very well understood. We report here that...

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Bibliografski detalji
Izdano u:EMBO Mol Med
Glavni autori: Singh, Karmveer, Maity, Pallab, Krug, Linda, Meyer, Patrick, Treiber, Nicolai, Lucas, Tanja, Basu, Abhijit, Kochanek, Stefan, Wlaschek, Meinhard, Geiger, Hartmut, Scharffetter-Kochanek, Karin
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309668/
https://ncbi.nlm.nih.gov/pubmed/25520316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404082
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