Superoxide anion radicals induce IGF-1 resistance through concomitant activation of PTP1B and PTEN

The evolutionarily conserved IGF-1 signalling pathway is associated with longevity, metabolism, tissue homeostasis, and cancer progression. Its regulation relies on the delicate balance between activating kinases and suppressing phosphatases and is still not very well understood. We report here that...

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Pubblicato in:EMBO Mol Med
Autori principali: Singh, Karmveer, Maity, Pallab, Krug, Linda, Meyer, Patrick, Treiber, Nicolai, Lucas, Tanja, Basu, Abhijit, Kochanek, Stefan, Wlaschek, Meinhard, Geiger, Hartmut, Scharffetter-Kochanek, Karin
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2015
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309668/
https://ncbi.nlm.nih.gov/pubmed/25520316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404082
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