Superoxide anion radicals induce IGF-1 resistance through concomitant activation of PTP1B and PTEN

The evolutionarily conserved IGF-1 signalling pathway is associated with longevity, metabolism, tissue homeostasis, and cancer progression. Its regulation relies on the delicate balance between activating kinases and suppressing phosphatases and is still not very well understood. We report here that...

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Detalles Bibliográficos
Publicado en:EMBO Mol Med
Main Authors: Singh, Karmveer, Maity, Pallab, Krug, Linda, Meyer, Patrick, Treiber, Nicolai, Lucas, Tanja, Basu, Abhijit, Kochanek, Stefan, Wlaschek, Meinhard, Geiger, Hartmut, Scharffetter-Kochanek, Karin
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2015
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309668/
https://ncbi.nlm.nih.gov/pubmed/25520316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404082
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