Smooth Muscle Specific Rac1 Deficiency Induces Hypertension by Preventing p116(RIP)(3)‐Dependent RhoA Inhibition

BACKGROUND: Increasing evidence implicates overactivation of RhoA as a critical component of the pathogenesis of hypertension. Although a substantial body of work has established that Rac1 functions antagonize RhoA in a broad range of physiological processes, the role of Rac1 in the regulation of va...

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Publicado en:J Am Heart Assoc
Autores principales: André, Gwennan, Sandoval, Juan E., Retailleau, Kevin, Loufrani, Laurent, Toumaniantz, Gilles, Offermanns, Stefan, Rolli‐Derkinderen, Malvyne, Loirand, Gervaise, Sauzeau, Vincent
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2014
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309079/
https://ncbi.nlm.nih.gov/pubmed/24938713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.000852
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