Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension

1. Inhibition of the type 5 phosphodiesterase and inhibition of Rho kinase are both effective in reducing pulmonary hypertension (PH). Here we investigate whether Rho kinase inhibition is involved in the beneficial effect of the type 5 phosphodiesterase inhibitor sildenafil on PH. 2. Chronic hypoxia...

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Bibliographic Details
Main Authors: Guilluy, Christophe, Sauzeau, Vincent, Rolli-Derkinderen, Malvyne, Guérin, Patrice, Sagan, Christine, Pacaud, Pierre, Loirand, Gervaise
Format: Artigo
Language:Inglês
Published: 2005
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751229/
https://ncbi.nlm.nih.gov/pubmed/16205723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706408
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