Biosynthesis of Versipelostatin: Identification of an Enzyme-Catalyzed [4+2]-Cycloaddition Required for Macrocyclization of Spirotetronate-Containing Polyketides

[Image: see text] Versipelostatin (VST) is an unusual 17-membered macrocyclic polyketide product that contains a spirotetronate skeleton. In this study, the entire VST biosynthetic gene cluster (vst) spanning 108 kb from Streptomyces versipellis 4083-SVS6 was identified by heterologous expression us...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Hashimoto, Takuya, Hashimoto, Junko, Teruya, Kuniko, Hirano, Takashi, Shin-ya, Kazuo, Ikeda, Haruo, Liu, Hung-wen, Nishiyama, Makoto, Kuzuyama, Tomohisa
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4308742/
https://ncbi.nlm.nih.gov/pubmed/25551461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja510711x
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