In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

One major bottleneck in natural product drug development is derivatization, which is pivotal for fine tuning lead compounds. A promising solution is modifying the biosynthetic machineries of middle molecules such as macrolides. Although intense studies have established various methodologies for prot...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Kudo, Kei, Hashimoto, Takuya, Hashimoto, Junko, Kozone, Ikuko, Kagaya, Noritaka, Ueoka, Reiko, Nishimura, Takehiro, Komatsu, Mamoru, Suenaga, Hikaru, Ikeda, Haruo, Shin-ya, Kazuo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419507/
https://ncbi.nlm.nih.gov/pubmed/32782248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17769-2
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars