In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

One major bottleneck in natural product drug development is derivatization, which is pivotal for fine tuning lead compounds. A promising solution is modifying the biosynthetic machineries of middle molecules such as macrolides. Although intense studies have established various methodologies for prot...

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Pubblicato in:Nat Commun
Autori principali: Kudo, Kei, Hashimoto, Takuya, Hashimoto, Junko, Kozone, Ikuko, Kagaya, Noritaka, Ueoka, Reiko, Nishimura, Takehiro, Komatsu, Mamoru, Suenaga, Hikaru, Ikeda, Haruo, Shin-ya, Kazuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419507/
https://ncbi.nlm.nih.gov/pubmed/32782248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17769-2
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