Designer Receptors Enhance Memory in a Mouse Model of Down Syndrome

Designer receptors exclusively activated by designer drugs (DREADDs) are novel and powerful tools to investigate discrete neuronal populations in the brain. We have used DREADDs to stimulate degenerating neurons in a Down syndrome (DS) model, Ts65Dn mice. Individuals with DS develop Alzheimer's...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Fortress, Ashley M., Hamlett, Eric D., Vazey, Elena M., Aston-Jones, Gary, Cass, Wayne A., Boger, Heather A., Granholm, Ann-Charlotte E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4308587/
https://ncbi.nlm.nih.gov/pubmed/25632113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2658-14.2015
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