Epigenetic Changes of EGFR play an important role in BRAF inhibitor Resistant Cutaneous Melanomas

BRAF mutations are frequent in cutaneous melanomas and BRAF inhibitors(BRAFi) have shown remarkable clinical efficacy in BRAF mutant melanoma patients. However, acquired drug resistance can occur rapidly and tumor(s) often progress thereafter. Various mechanisms of BRAFi resistance have recently bee...

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Veröffentlicht in:J Invest Dermatol
Hauptverfasser: Wang, Jinhua, Huang, Sharon K., Marzese, Diego M., Hsu, Sandy C., Kawas, Neal P., Chong, Kelly K., Long, Georgina V., Menzies, Alexander M., Scolyer, Richard A., Izraely, Sivan, Sagi-Assif, Orit, Witz, Isaac P., Hoon, Dave S.B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4307785/
https://ncbi.nlm.nih.gov/pubmed/25243790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2014.418
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