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Cellular uptake and nuclear binding of insulin in human cultured lymphocytes: evidence for potential intracellular sites of insulin action.

Human cultured lymphocytes (IM-9) were used to demonstrate that insulin can enter the intact cell and bind to the nucleus. When these lymphocytes were incubated with 125I-labeled insulin, specific cellular uptake reached a maximum within 2 min and remained at a plateau for 90 min or longer. Partiall...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Goldfine, I D, Smith, G J, Wong, K Y, Jones, A L
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 1977
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC430761/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/193098/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.4.1368
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