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Decreased fidelity of DNA polymerase activity isolated from aging human fibroblasts.
DNA polymerase (deoxynucleosidetriphosphate: DNA nucleotidyltransferase, EC 2.7.7.7 or DNA nucleotidyltransferase) activity, isolated from late and early passage cells of the diploid human fibroblast line, MRC-5, was compared. The level of activity dropped with increasing passage. In addition, when...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1976
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC430760/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1066693/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.73.8.2818 |
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