Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung

BACKGROUND: Earlier studies have reported that transforming growth factor beta 1(TGFβ1) is a critical mediator of hyperoxia-induced acute lung injury (HALI) in developing lungs, leading to impaired alveolarization and a pulmonary phenotype of bronchopulmonary dysplasia (BPD). However, the mechanisms...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Sureshbabu, Angara, Syed, Mansoor A, Boddupalli, Chandra Sekhar, Dhodapkar, Madhav V, Homer, Robert J, Minoo, Parviz, Bhandari, Vineet
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4307226/
https://ncbi.nlm.nih.gov/pubmed/25591994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-014-0162-6
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