A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung

BACKGROUND: Transforming growth factor-beta 1 (TGF-β1) has been implicated in hyperoxia-induced cell death and impaired alveolarization in the developing lung. In addition, the c-JunNH2-terminal kinase (JNK) pathway has been shown to have a role for TGF-β1-mediated effects. We hypothesized that the...

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Main Authors: Li, Zhang, Choo-Wing, Rayman, Sun, Huanxing, Sureshbabu, Angara, Sakurai, Reiko, Rehan, Virender K, Bhandari, Vineet
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266206/
https://ncbi.nlm.nih.gov/pubmed/22172122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-12-54
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