Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene.

Benzo(a)pyrene is metabolically and stereospecifically converted by mixed-function oxidases of rat liver microsomes and epoxide hydratase (glycol hydro-lyase (epoxide-forming), EC 4.2.1.63)to the single enantiomer (-)r-7,t-8-dihydroxy-7,8-dihydrobenzol (A) pyrene. This enantiomer is further metaboli...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Yang, S K, McCourt, D W, Roller, P P, Gelboin, H V
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1976
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC430694/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1066669/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.73.8.2594
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