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Novel Para-Phenyl Substituted Diindolylmethanes Protect Against MPTP Neurotoxicity and Suppress Glial Activation in a Mouse Model of Parkinson’s Disease

The orphan nuclear receptor NR4A2 (Nurr1) constitutively regulates inflammatory gene expression in glial cells by suppressing DNA binding activity of NF-κB. We recently reported that novel 1,1-bis(3′-indolyl)-1-(p-substitutedphenyl)methane (C-DIM) compounds that activate NR4A family nuclear receptor...

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書目詳細資料
發表在:Toxicol Sci
Main Authors: De Miranda, Briana R., Popichak, Katriana A., Hammond, Sean L., Miller, James A., Safe, Stephen, Tjalkens, Ronald B.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306720/
https://ncbi.nlm.nih.gov/pubmed/25406165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu236
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