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Ablation of AMPKα1 and α2 from pancreatic beta cells and RIP.Cre neurons suppresses insulin release in vivo
AIMS/HYPOTHESIS: AMP-activated protein kinase (AMPK) is an evolutionarily-conserved enzyme and a target of antihyperglycemic agents including metformin. However, the precise role(s) of the enzyme in controlling insulin secretion remains uncertain. METHODS: The catalytic α1 and α2 subunits of AMPK we...
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| Publicado no: | Diabetologia |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4306708/ https://ncbi.nlm.nih.gov/pubmed/20221584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-010-1692-1 |
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