LKB1 deletion with the RIP2.Cre transgene modifies pancreatic β-cell morphology and enhances insulin secretion in vivo

The tumor suppressor liver kinase B1 (LKB1), also called STK11, is a protein kinase mutated in Peutz-Jeghers syndrome. LKB1 phosphorylates AMP-activated protein kinase (AMPK) and several related protein kinases. Whereas deletion of both catalytic isoforms of AMPK from the pancreatic β-cell and hypot...

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Main Authors: Sun, Gao, Tarasov, Andrei I., McGinty, James A., French, Paul M., McDonald, Angela, Leclerc, Isabelle, Rutter, Guy A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886523/
https://ncbi.nlm.nih.gov/pubmed/20354156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00100.2010
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