Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

BACKGROUND: The incidence of hematologic cancers increases with age. These cancers are associated with recurrent somatic mutations in specific genes. We hypothesized that such mutations would be detectable in the blood of some persons who are not known to have hematologic disorders. METHODS: We anal...

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Detalhes bibliográficos
Publicado no:N Engl J Med
Main Authors: Jaiswal, Siddhartha, Fontanillas, Pierre, Flannick, Jason, Manning, Alisa, Grauman, Peter V., Mar, Brenton G., Lindsley, R. Coleman, Mermel, Craig H., Burtt, Noel, Chavez, Alejandro, Higgins, John M., Moltchanov, Vladislav, Kuo, Frank C., Kluk, Michael J., Henderson, Brian, Kinnunen, Leena, Koistinen, Heikki A., Ladenvall, Claes, Getz, Gad, Correa, Adolfo, Banahan, Benjamin F., Gabriel, Stacey, Kathiresan, Sekar, Stringham, Heather M., McCarthy, Mark I., Boehnke, Michael, Tuomilehto, Jaakko, Haiman, Christopher, Groop, Leif, Atzmon, Gil, Wilson, James G., Neuberg, Donna, Altshuler, David, Ebert, Benjamin L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306669/
https://ncbi.nlm.nih.gov/pubmed/25426837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1408617
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