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Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation
Tau hyperphosphorylation is thought to underlie tauopathy. Working in a Drosophila tauopathy model expressing a human Tau mutant (hTauR406W, or Tau*), we show that zinc contributes to the development of Tau toxicity through two independent actions: by increasing Tau phosphorylation and, more signifi...
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| Publicat a: | Cell Rep |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4306234/ https://ncbi.nlm.nih.gov/pubmed/25066125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.047 |
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