Yeast DNA ligase IV mutations reveal a nonhomologous end joining function of BRCT1 distinct from XRCC4/Lif1 binding

LIG4/Dnl4 is the DNA ligase that (re)joins DNA double-strand breaks (DSBs) via nonhomologous end joining (NHEJ), an activity supported by binding of its tandem BRCT domains to the ligase accessory protein XRCC4/Lif1. We screened a panel of 88 distinct ligase mutants to explore the structure-function...

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Publicado en:DNA Repair (Amst)
Main Authors: Chiruvella, Kishore K., Renard, Brian M., Birkeland, Shanda R., Sunder, Sham, Liang, Zhuobin, Wilson, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305023/
https://ncbi.nlm.nih.gov/pubmed/25457772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.10.003
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