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De Novo CNV Formation in Mouse Embryonic Stem Cells Occurs in the Absence of Xrcc4-Dependent Nonhomologous End Joining

Spontaneous copy number variant (CNV) mutations are an important factor in genomic structural variation, genomic disorders, and cancer. A major class of CNVs, termed nonrecurrent CNVs, is thought to arise by nonhomologous DNA repair mechanisms due to the presence of short microhomologies, blunt ends...

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Detalhes bibliográficos
Main Authors: Arlt, Martin F., Rajendran, Sountharia, Birkeland, Shanda R., Wilson, Thomas E., Glover, Thomas W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447954/
https://ncbi.nlm.nih.gov/pubmed/23028374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002981
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