Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

The HIV-1 envelope (Env) mediates viral entry into host cells. To enable the direct imaging of conformational dynamics within Env, we introduced fluorophores into variable regions of the glycoprotein gp120 subunit and measured single-molecule fluorescence resonance energy transfer within the context...

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Udgivet i:Science
Main Authors: Munro, James B., Gorman, Jason, Ma, Xiaochu, Zhou, Zhou, Arthos, James, Burton, Dennis R., Koff, Wayne C., Courter, Joel R., Smith, Amos B., Kwong, Peter D., Blanchard, Scott C., Mothes, Walther
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304640/
https://ncbi.nlm.nih.gov/pubmed/25298114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1254426
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