Discovery of Highly Potent Tyrosinase Inhibitor, T1, with Significant Anti-Melanogenesis Ability by zebrafish in vivo Assay and Computational Molecular Modeling

Tyrosinase is involved in melanin biosynthesis and the abnormal accumulation of melanin pigments leading to hyperpigmentation disorders that can be treated with depigmenting agents. A natural product T1, bis(4-hydroxybenzyl)sulfide, isolated from the Chinese herbal plant, Gastrodia elata, is a stron...

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Pubblicato in:Sci Rep
Autori principali: Chen, Wang-Chuan, Tseng, Tien-Sheng, Hsiao, Nai-Wan, Lin, Yun-Lian, Wen, Zhi-Hong, Tsai, Chin-Chuan, Lee, Yu-Ching, Lin, Hui-Hsiung, Tsai, Keng-Chang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303873/
https://ncbi.nlm.nih.gov/pubmed/25613357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07995
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