Probing Substrate Interactions in the Active Tunnel of a Catalytically Deficient Cellobiohydrolase (Cel7)

Cellobiohydrolases break down cellulose sequentially by sliding along the crystal surface with a single cellulose strand threaded through the catalytic tunnel of the enzyme. This so-called processive mechanism relies on a complex pattern of enzyme-substrate interactions, which need to be addressed i...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Colussi, Francieli, Sørensen, Trine H., Alasepp, Kadri, Kari, Jeppe, Cruys-Bagger, Nicolaj, Windahl, Michael S., Olsen, Johan P., Borch, Kim, Westh, Peter
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2015
Ämnen:
Enzymology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303693/
https://ncbi.nlm.nih.gov/pubmed/25477511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.624163
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