The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

The conversion of α-synuclein from its intrinsically disordered monomeric state into the fibrillar cross-β aggregates characteristically present in Lewy bodies is largely unknown. The investigation of α-synuclein variants causative of familial forms of Parkinson disease can provide unique insights i...

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Publicado en:J Biol Chem
Autores principales: Porcari, Riccardo, Proukakis, Christos, Waudby, Christopher A., Bolognesi, Benedetta, Mangione, P. Patrizia, Paton, Jack F. S., Mullin, Stephen, Cabrita, Lisa D., Penco, Amanda, Relini, Annalisa, Verona, Guglielmo, Vendruscolo, Michele, Stoppini, Monica, Tartaglia, Gian Gaetano, Camilloni, Carlo, Christodoulou, John, Schapira, Anthony H. V., Bellotti, Vittorio
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303689/
https://ncbi.nlm.nih.gov/pubmed/25505181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.610527
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