First Evidence for Substrate Channeling between Proline Catabolic Enzymes: A VALIDATION OF DOMAIN FUSION ANALYSIS FOR PREDICTING PROTEIN-PROTEIN INTERACTIONS

Proline dehydrogenase (PRODH) and Δ(1)-pyrroline-5-carboxylate (P5C) dehydrogenase (P5CDH) catalyze the four-electron oxidation of proline to glutamate via the intermediates P5C and l-glutamate-γ-semialdehyde (GSA). In Gram-negative bacteria, PRODH and P5CDH are fused together in the bifunctional en...

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Vydáno v:J Biol Chem
Hlavní autoři: Sanyal, Nikhilesh, Arentson, Benjamin W., Luo, Min, Tanner, John J., Becker, Donald F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303673/
https://ncbi.nlm.nih.gov/pubmed/25492892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625483
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