Constitutive Activation of Epidermal Growth Factor Receptor Promotes Tumorigenesis of Cr(VI)-transformed Cells through Decreased Reactive Oxygen Species and Apoptosis Resistance Development

Hexavalent chromium (Cr(VI)) compounds are well-established lung carcinogens. Epidermal growth factor receptor (EGFR) is a tyrosine kinase transmembrane receptor that regulates cell survival, tumor invasion, and angiogenesis. Our results show that chronic exposure of human bronchial epithelial (BEAS...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Kim, Donghern, Dai, Jin, Fai, Leonard Yenwong, Yao, Hua, Son, Young-Ok, Wang, Lei, Pratheeshkumar, Poyil, Kondo, Kazuya, Shi, Xianglin, Zhang, Zhuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303672/
https://ncbi.nlm.nih.gov/pubmed/25477514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.619783
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