Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.

Insulin treatment of mammalian cells immediately stimulates the tyrosine phosphorylation of a cellular protein of 185 kDa referred to as pp185 or IRS-1 (insulin receptor substrate 1). The potential role of the IRS-1 protein in insulin signaling has been examined by microinjecting affinity-purified a...

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Bibliographische Detailangaben
Hauptverfasser: Rose, D W, Saltiel, A R, Majumdar, M, Decker, S J, Olefsky, J M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC43036/
https://ncbi.nlm.nih.gov/pubmed/8290602
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