Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.
Insulin treatment of mammalian cells immediately stimulates the tyrosine phosphorylation of a cellular protein of 185 kDa referred to as pp185 or IRS-1 (insulin receptor substrate 1). The potential role of the IRS-1 protein in insulin signaling has been examined by microinjecting affinity-purified a...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1994
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43036/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8290602/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.2.797 |
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