Rescuing dicer defects via inhibition of an anti-dicing nuclease

Genetic defects in the microRNA (miRNA) generating enzyme, dicer, are increasingly linked to disease. Loss of miRNA in dicer deficiency is thought to be due to loss of miRNA-generating activity. Here, we demonstrate a previously unknown catabolic mechanism driving miRNA depletion in dicer deficiency...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Rep
Päätekijät: Asada, Ken, Canestrari, Emanuele, Fu, Xiuping, Li, Zhi, Makowski, Edward, Wu, Yen-Ching, Mito, Jeffrey K., Kirsch, David G., Baraban, Jay, Paroo, Zain
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303555/
https://ncbi.nlm.nih.gov/pubmed/25457613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.021
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