Rescuing dicer defects via inhibition of an anti-dicing nuclease

Genetic defects in the microRNA (miRNA) generating enzyme, dicer, are increasingly linked to disease. Loss of miRNA in dicer deficiency is thought to be due to loss of miRNA-generating activity. Here, we demonstrate a previously unknown catabolic mechanism driving miRNA depletion in dicer deficiency...

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Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Asada, Ken, Canestrari, Emanuele, Fu, Xiuping, Li, Zhi, Makowski, Edward, Wu, Yen-Ching, Mito, Jeffrey K., Kirsch, David G., Baraban, Jay, Paroo, Zain
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303555/
https://ncbi.nlm.nih.gov/pubmed/25457613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.021
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