Rescuing dicer defects via inhibition of an anti-dicing nuclease

Genetic defects in the microRNA (miRNA) generating enzyme, dicer, are increasingly linked to disease. Loss of miRNA in dicer deficiency is thought to be due to loss of miRNA-generating activity. Here, we demonstrate a previously unknown catabolic mechanism driving miRNA depletion in dicer deficiency...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Asada, Ken, Canestrari, Emanuele, Fu, Xiuping, Li, Zhi, Makowski, Edward, Wu, Yen-Ching, Mito, Jeffrey K., Kirsch, David G., Baraban, Jay, Paroo, Zain
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303555/
https://ncbi.nlm.nih.gov/pubmed/25457613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.021
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