Targeting Oncogenic Interleukin-7 Receptor Signalling with N-acetylcysteine in T-cell acute lymphoblastic leukaemia

Activating mutations of the interleukin-7 receptor (IL7R) occur in approximately 10% of patients with T-cell acute lymphoblastic leukaemia (T-ALL). Most mutations generate a cysteine at the transmembrane domain leading to receptor homodimerization through disulfide bond formation and ligand-independ...

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Detalhes bibliográficos
Publicado no:Br J Haematol
Main Authors: Mansour, Marc R., Reed, Casie, Eisenberg, Amy R., Tseng, Jen-Chieh, Twizere, Jean-Claude, Daakour, Sarah, Yoda, Akinori, Rodig, Scott J., Tal, Noa, Shochat, Chen, Berezovskaya, Alla, DeAngelo, Daniel J., Sallan, Stephen E., Weinstock, David M., Izraeli, Shai, Kung, Andrew L., Kentsis, Alex, Look, A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303513/
https://ncbi.nlm.nih.gov/pubmed/25256574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.13115
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