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RNASeq-derived transcriptome comparisons reveal neuromodulatory deficiency in the CO(2) insensitive brown Norway rat

Raphé-derived serotonin (5-HT) and thyrotropin-releasing hormone (TRH) play important roles in fundamental, homeostatic control systems such as breathing and specifically the ventilatory CO(2) chemoreflex. Brown Norway (BN) rats exhibit an inherent and severe ventilatory insensitivity to hypercapnia...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Physiol
Hauptverfasser: Puissant, Madeleine M, Echert, Ashley E, Yang, Chun, Mouradian, Gary C, Novotny, Tyler, Liu, Pengyuan, Liang, Mingyu, Hodges, Matthew R
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303386/
https://ncbi.nlm.nih.gov/pubmed/25630262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.285171
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