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Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells

In the epididymis, low luminal bicarbonate and acidic pH maintain sperm quiescent during maturation and storage. The vacuolar H(+)-ATPase (V-ATPase) in epididymal clear cells plays a major role in luminal acidification. We have shown previously that cAMP, luminal alkaline pH, and activation of the b...

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Pubblicato in:Am J Physiol Cell Physiol
Autori principali: Pastor-Soler, Núria M., Hallows, Kenneth R., Smolak, Christy, Gong, Fan, Brown, Dennis, Breton, Sylvie
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303256/
https://ncbi.nlm.nih.gov/pubmed/18160485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00537.2007
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